ACROBiosystems社 プロダクトリスト：Recombinant Protein
- Mouse B7-H3 / CD276 Protein, Fc Tag
|Synonyms||B7-H3,CD276,B7 homolog 3|
|Characteristics||This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.1 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Endotoxin Level||Less than 1.0 EU per μg by the LAL method.|
|Purity||>95% as determined by SDS-PAGE.|
|Description||B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.|
|Reference||(1) Chapoval A.I., et al., 2001, Nat. Immunol. 2:269-274.
(2) Castriconi R., et al., 2004, Proc. Natl. Acad. Sci. U.S.A. 101:12640-12645.
(3) Wang L., et al., 2005, Eur. J. Immunol. 35:428-438.