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タンパク質カタログ
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- サプライヤー
- AcroBioSystems
- カタログNo.
- B71-H82E9
- 製品名称
- Biotinylated Human B7-1 / CD80 Protein, Avitag?,His Tag (recommended for biopanning) (MALS verified)
- タンパク質名
- B7-1
- Species
- Human
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries an Avi tag (Avitag?) at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 26.5 kDa. The protein migrates as 44-54 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | N/A |
| Purity | 95% |
| Description | B7-1 and B7-2, together with their receptors CD28 and CTLA?4, constitute one of the dominant co-stimulatory pathways that regulate T? and B?cell responses. Although both CTLA?4 and CD28 can bind to the same ligands, CTLA?4 binds to B7?1 and B7?2 with a 20 ? 100 fold higher affinity than CD28 and is involved in the down?regulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas. |
| Reference | - |
| URL | https://www.acrobiosystems.com/products/protein/b7-1-human-b71-h82e9 |
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