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タンパク質カタログ
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- サプライヤー
- AcroBioSystems
- カタログNo.
- ALN-H51H4
- 製品名称
- Human Alpha-Synuclein Pre-formed Fibrils Protein, His Tag
- タンパク質名
- Alpha-Synuclein
- Species
- Human
- HOST
- E. coli
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.3 kDa. |
| Endotoxin Level | 1.0 EU per μg |
| Purity | 90% |
| Description | Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration. |
| Reference | - |
| URL | https://www.acrobiosystems.com/products/protein/alpha-synuclein-human-aln-h51h4 |
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