Human Alpha-Synuclein (E46K) Protein, Tag Free (MALS verified) [ALN-H5117]

Synonyms	-
Characteristics	This protein carries no "tag". The protein has a calculated MW of 14.5 kDa. The protein migrates as 16 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin Level	1.0 EU per μg
Purity	95%
Description	Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
Reference	-
URL	https://www.acrobiosystems.com/P5565-Human-Alpha-Synuclein-%28E46K%29-Protein-Tag-Free-%28MALS-verified%29.html

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