Cynomolgus Alpha-Synuclein Protein, His Tag (MALS verified) [ALN-C52H5]

Synonyms	-
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.4 kDa. The protein migrates as 18-20 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin Level	1.0 EU per μg
Purity	95%
Description	Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
Reference	-
URL	https://www.acrobiosystems.com/P5350-Cynomolgus-Alpha-Synuclein-Protein-His-Tag-%28MALS-verified%29.html

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