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タンパク質カタログ
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- サプライヤー
- AcroBioSystems
- カタログNo.
- ACB-H5253
- 製品名称
- Human Activin RIB & Activin RIIB Protein, Fc Tag&Fc Tag
- タンパク質名
- Activin RIB & Activin RIIB
- Species
- Human
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | Human Activin RIB & Activin RIIB Protein, Fc Tag&Fc Tag is produced by co-expression of Activin RIB and Activin RIIB, has a calculated MW of 37 kDa & 39.1 kDa. Subunit Activin RIB is fused with a human IgG1 Fc tag at the C-terminus and subunit Activin RIIB is fused with a human IgG1 Fc tag at the C-terminus. The protein migrates as 80-95 kDa and >150 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | 1.0 EU per μg |
| Purity | 90% |
| Description | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. |
| Reference | - |
| URL | https://www.acrobiosystems.com/products/protein/activin-rib-activin-riib-human-acb-h5253 |
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