Human FcRn binding Kit (TR-FRET) [FRT-01] | ナミキ商事株式会社

リコンビナントタンパク質

ACROBiosystems社プロダクトリスト：Kit

サプライヤー: AcroBioSystems
カタログNo.: FRT-01
製品名称: Human FcRn binding Kit (TR-FRET)
Species: Human

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Overview

Description	FcRn is a heterodimer comprising a β2-microglobulin (β2m) light chain and a major histocompatibility complex class I-like heavy chain. It is widely accepted that the interaction of IgGs with the Fc receptor (FcRn) plays a critical role in regulating IgG homeostasis in vivo. FcRn interacts with the CH2-CH3 portion of the Fc domain of IgGs in a tightly regulated pH-dependent manner with high affinity binding occurring at an acidic (pH=6) and weak to no binding interactions as the pH is raised to neutral (7.4). FcRn is responsible for the extended serum half-life of IgG and also serum albumin, and for the transport across endothelial and epithelial barriers, increasing the overall bioavailability of IgG and serum albumin. The binding affinity between FcRn and IgG are commonly used to characterize the metabolic levels of antibody drugs. The Human FcRn Binding Kit (TR-FRET) can detect the binding of IgG Fc region to the human FcRn receptor in homogeneous system within 0.5-1 hours. it is high sensitive, short detection time and easy to use.
URL	https://www.acrobiosystems.com/P7366-Human-FcRn-binding-Kit-%28TR-FRET%29.html

Description

FcRn is a heterodimer comprising a β2-microglobulin (β2m) light chain and a major histocompatibility complex class I-like heavy chain. It is widely accepted that the interaction of IgGs with the Fc receptor (FcRn) plays a critical role in regulating IgG homeostasis in vivo. FcRn interacts with the CH2-CH3 portion of the Fc domain of IgGs in a tightly regulated pH-dependent manner with high affinity binding occurring at an acidic (pH=6) and weak to no binding interactions as the pH is raised to neutral (7.4). FcRn is responsible for the extended serum half-life of IgG and also serum albumin, and for the transport across endothelial and epithelial barriers, increasing the overall bioavailability of IgG and serum albumin. The binding affinity between FcRn and IgG are commonly used to characterize the metabolic levels of antibody drugs.
The Human FcRn Binding Kit (TR-FRET) can detect the binding of IgG Fc region to the human FcRn receptor in homogeneous system within 0.5-1 hours. it is high sensitive, short detection time and easy to use.

URL

https://www.acrobiosystems.com/P7366-Human-FcRn-binding-Kit-%28TR-FRET%29.html

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リコンビナントタンパク質

ACROBiosystems社 プロダクトリスト：Kit

Overview

ACROBiosystems社プロダクトリスト：Kit