| Description |
Programmed death molecule 1 and its ligand (PD-1/PD-L1) are a pair of negative immune costimulatory molecules. Under normal circumstances, the combination of PD-L1 on tissue cell surface and PD-1 on lymphocyte surface can inhibit lymphocyte function and induce apoptosis of activated lymphocyte, thus playing an autoimmune tolerance role. However, pD-L1 is also expressed on the surface of various tumor cells. Pd-l1 expressed by tumor cells can bind to PD-1 on the surface of corresponding lymphocytes, inhibit the function of lymphocytes and the release of cytokines, and induce apoptosis of lymphocytes, leading to immune escape of tumor cells. Therefore, blocking the PD-1/PD-L1 pathway can enhance lymphocyte activity to achieve the effect of tumor immunotherapy. |
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