検索タンパク質、抗体、アッセイキット
アッセイキットカタログ
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- サプライヤー
- AcroBioSystems
- カタログNo.
- CEA-C202
- 製品名称
- Human PCSK9 ELISA Kit
- Species
- Human
- 96tests: 139,440円
- お問い合わせ
Overview
| Description | Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3). |
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| URL | https://www.acrobiosystems.com/P7731-ClinMax%E2%84%A2-Human-PCSK9-ELISA-Kit.html |
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