タンパク質(癌免疫療法用)
ACROBiosystems社 プロダクトリスト:Recombinant Protein
- サプライヤー
- AcroBioSystems
- カタログNo.
- TFI-C52H3
- 製品名称
- Rhesus macaque TFPI Protein
- タンパク質名
- TFPI
- Species
- Rhesus macaque
- HOST
- HEK293
Overview
Synonyms | TFPI,LACI,TFPI1,EPI,TFI |
---|---|
Characteristics | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 31.1 kDa. The protein migrates as 41-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Endotoxin Level | Less than 1.0 EU per μg by the LAL method. |
Purity | >95% as determined by SDS-PAGE. |
Description | Tissue factor pathway inhibitor (TFPI) is also known as Extrinsic pathway inhibitor (EPI), Lipoprotein - associated coagulation inhibitor (LACI), is a plasma proteinase inhibitor synthesized by vascular endothelial cells and part of it is associated with glycosaminoglycans of these cells. TFPI is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). TFPI is a secreted protein with a N?terminal acidic region, three Kunitz (K) domains separated with by two linker regions, and a C?terminal basic region. The first K domain inhibits coagulation factor VIIa complexed to tissue factor (TF); The second K domain inhibits factor Xa; The third K domain binds to heparin; The C?terminal basic region may have several functions. For example, it plays an important role in binding of TFPI to cell surfaces. |
Reference | (1) Bajaj MS., et al., 2001, Thromb Haemost., 86:959. (2) Mine S., et al., 2002, Biochemistry, 41:78. (3) Witt I., et al., 2002, Hamostaseologie, 22:30?35. |
URL | https://www.acrobiosystems.com/P1747-Rhesus-Macaque-TFPI-Protein.html |