Rhesus macaque TFPI Protein [TFI-C52H3] | ナミキ商事株式会社

Synonyms	TFPI,LACI,TFPI1,EPI,TFI
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 31.1 kDa. The protein migrates as 41-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	Less than 1.0 EU per μg by the LAL method.
Purity	>95% as determined by SDS-PAGE.
Description	Tissue factor pathway inhibitor (TFPI) is also known as Extrinsic pathway inhibitor (EPI), Lipoprotein - associated coagulation inhibitor (LACI), is a plasma proteinase inhibitor synthesized by vascular endothelial cells and part of it is associated with glycosaminoglycans of these cells. TFPI is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). TFPI is a secreted protein with a N?terminal acidic region, three Kunitz (K) domains separated with by two linker regions, and a C?terminal basic region. The first K domain inhibits coagulation factor VIIa complexed to tissue factor (TF); The second K domain inhibits factor Xa; The third K domain binds to heparin; The C?terminal basic region may have several functions. For example, it plays an important role in binding of TFPI to cell surfaces.
Reference	(1) Bajaj MS., et al., 2001, Thromb Haemost., 86:959. (2) Mine S., et al., 2002, Biochemistry, 41:78. (3) Witt I., et al., 2002, Hamostaseologie, 22:30?35.
URL	https://www.acrobiosystems.com/P1747-Rhesus-Macaque-TFPI-Protein.html

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