ACROBiosystems社 プロダクトリスト：Recombinant Protein
- Human IL-13 Protein, Tag Free
|Characteristics||This protein carries no "tag". The protein has a calculated MW of 13.4 kDa. The protein migrates as 20-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Endotoxin Level||Less than 1.0 EU per μg by the LAL method.|
|Purity||>92% as determined by SDS-PAGE.|
|Description||Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.|
|Reference||(1) Wynn TA., 2003, Annu. Rev. Immunol., 21: 425-456.
(2) Wills-Karp M, et al., 1998, Science, 282 (5397): 2258-2261.
(3) Zurawski G., et al., 1994, Immunol. Today., 15 (1): 19-26.