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ACROBiosystems社 プロダクトリスト:Recombinant Protein

サプライヤー
AcroBioSystems
カタログNo.
IL3-H4217
製品名称
Human IL-13 Protein, Tag Free
タンパク質名
IL-13
Species
Human
HOST
HEK293
50ug: 95,000円
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500ug: 504,000円
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Overview

Synonyms IL13,ALRH,BHR1,MGC116786,MGC116788,MGC116789,P600,Interleukin-13
Characteristics This protein carries no "tag". The protein has a calculated MW of 13.4 kDa. The protein migrates as 20-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Purity >92% as determined by SDS-PAGE.
Description Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.
Reference (1) Wynn TA., 2003, Annu. Rev. Immunol., 21: 425-456.
(2) Wills-Karp M, et al., 1998, Science, 282 (5397): 2258-2261.
(3) Zurawski G., et al., 1994, Immunol. Today., 15 (1): 19-26.
URL http://www.acrobiosystems.com/P2350-Human-IL-13-Protein.html

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