ACROBiosystems社 プロダクトリスト：Recombinant Protein
- Rhesus macaque DDR2 Protein, Fc Tag
- Rhesus macaque
|Characteristics||This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 69.3 kDa. The protein migrates as 80-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Endotoxin Level||Less than 1.0 EU per μg by the LAL method.|
|Purity||>95% as determined by SDS-PAGE.|
|Description||Discoidin domain-containing receptor 2 (DDR2) is also known as CD167 antigen-like family member B (CD167b), Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3(NTRKR3), Tyrosine-protein kinase TYRO10, Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. DDR2 is required for normal bone development. DDR2 regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. DDR2 regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. DDR2 promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.|
|Reference||(1) Gibbs R.A., et al., 2007, Science 316:222-234.
(2) Xu L., et al., 2007, Arthritis Rheum. 56:2663-2673.
(3) Konitsiotis A.D., et al., 2008, J. Biol. Chem. 283:6861-6868.