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ACROBiosystems社 プロダクトリスト:Recombinant Protein

サプライヤー
AcroBioSystems
カタログNo.
CT4-M52A3
製品名称
Mouse CTLA-4 / CD152 Protein, mouse IgG2a Fc Tag, low endotoxin
タンパク質名
CTLA-4
Species
Mouse
HOST
HEK293
100ug: 61,000円
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1mg: 378,000円
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Overview

Synonyms CTLA4,CD152
Characteristics This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 41.1 kDa. As a result of glycosylation, the protein migrates as 50-66 kDa under reducing (R) condition, and 95-105 kDa under non-reducing (NR) condition (SDS-P
Endotoxin Level Less than 0.1 EU per μg by the LAL method.
Purity >95% as determined by SDS-PAGE.
Description CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
Reference (1) Waterhouse P, et al., 1995, Science 270 (5238): 985?8.
(2) Magistrelli G, et al., 1999. Eur. J. Immunol. 29 (11): 3596?602.
(3) Rudd, CE. et al., 2009, Immunol. Rev.?229?(1): 12-26.
URL https://www.acrobiosystems.com/P2163-Mouse-CTLA-4--CD152-Protein-mouse-IgG2a-Fc-Tag.html

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