ACROBiosystems社 プロダクトリスト：Recombinant Protein
- Mouse CTLA-4 / CD152 Protein, mouse IgG2a Fc Tag, low endotoxin
|Characteristics||This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 41.1 kDa. As a result of glycosylation, the protein migrates as 50-66 kDa under reducing (R) condition, and 95-105 kDa under non-reducing (NR) condition (SDS-PAGE).|
|Endotoxin Level||Less than 0.1 EU per μg by the LAL method.|
|Purity||>95% as determined by SDS-PAGE.|
|Description||CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.|
|Reference||(1) Waterhouse P, et al., 1995, Science 270 (5238): 985?8.
(2) Magistrelli G, et al., 1999. Eur. J. Immunol. 29 (11): 3596?602.
(3) Rudd, CE. et al., 2009, Immunol. Rev.?229?(1): 12-26.