ACROBiosystems社 プロダクトリスト：Recombinant Protein
- Mouse CCL6 / C10 Protein
|Characteristics||This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 11.4 kDa. The protein migrates as 14 kDa under reducing (R) condition (SDS-PAGE).|
|Endotoxin Level||Less than 1.0 EU per μg by the LAL method.|
|Purity||>90% as determined by SDS-PAGE.|
|Description||Chemokine (C-C motif) ligand 6 (CCL6), a member of the CC chemokine family, was initially identified as a transcript that is induced in bone marrow cells upon stimulation with GM?CSF. CCL6 has only been identified in rodents, A?human?homologue?for?mouse?CCL6?has?not?been?identified.??The?mCCL6?cDNA?encodes?a?116?amino?acid?residue?precursor?protein?with?a?hydrophobic?signal?peptide?that?is?cleaved?to?yield?a?95?amino?acid?residue?mature?protein. In mice, CCL6 is expressed in cells from neutrophil and macrophage lineages, where?it?is?strongly?induced?upon?GM?CSF?(Cat. # GMF-H4214) stimulation. Mouse CCL6 expression was also shown to be strongly induced by IL-4 (Cat. # IL4-H4218) in mouse macrophages and by cytokine IL?13 (Cat. # IL3-H4210) in mouse lung. Mouse CCL6 is located on chromosome 11. The cell surface receptor for CCL6 is believed to be the chemokine receptor CCR1.|
|Reference||(1) Orlofsky, et al., 1991, Cell Regul. 2 (5), 403-412.
(2) Ma., et al., 2004, J Immunol.172(3):1872-81.
(3) Berger., et al., 1993, DNA Cell Biol. 12 (9), 839-847.
(4) Kanno M, et al., 2005, J Neuroimmunol. 167(1-2): 72-80.