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ACROBiosystems社 プロダクトリスト:Recombinant Protein

サプライヤー
AcroBioSystems
カタログNo.
CAE-M5222
製品名称
Mouse Carboxypeptidase E / CPE Protein
タンパク質名
Carboxypeptidase E
Species
Mouse
HOST
HEK293
100ug: 53,000円
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1mg: 404,000円
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Overview

Synonyms Carboxypeptidase E,CPE,carboxypeptidase,enkephalin convertase,CPH
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 52 kDa. The protein migrates as 52 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Purity >95% as determined by SDS-PAGE.
Description Carboxypeptidase E (CPE) is also known as Carboxypeptidase H or enkephalin convertase. Carboxypeptidase E cleaves C-terminal amino acid residues and is involved in neuropeptide processing. It is a peripheral membrane protein. CPE specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Carboxypeptidase E appears to have several functions. The active form of carboxypeptidase E was shown to be in secretory vesicles, where it acts as an exopeptidase to activate neuropeptides, It does that by cleaving off basic C-terminal amino acids, producing the active form of the peptide. Products of carboxypeptidase E include insulin, enkephalin, and most other neuroendocrine peptides.It has also been proposed that membrane-associated carboxypeptidase E acts as a sorting signal for regulated secretory proteins in the trans-Golgi network of the pituitary and in secretory granules; regulated secretory proteins are mostly hormones and neuropeptides. Mice with mutant carboxypeptidase E Cpe, display endocrine disorders like obesity and infertility.
Reference (1) Manser, E. et al., 1990, Biochem. J. 267: 517-525.
(2) Jeffrey, K.D. et al., 2008, Proc. Natl. Acad. Sci. U.S.A. 105: 8452-8457.
(3) Dhanvantari,S. et al., 2000, J. Biol. Chem. 275: 29887-29893.
URL http://www.acrobiosystems.com/P235-Mouse-Carboxypeptidase-E-CPE-Protein.html

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