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| MedChemExpress (MCE) provides a wide range of life-science biochemicals, including more than 100,000 bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use. If you need these products, please do not hesitate to contact us via sales@MedChemExpress.com. |
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CAS No.: 1135688-25-3
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Research Area: Caspase/Cancer
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An irreversible caspase-4 peptide inhibitor with a broad-spectrum anticancer activity. |
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Selectively and effectively blocks endoplasmic reticulum (ER) stress-induced apoptosis in many cancer cells. |
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Solubility: DMSO : 125 mg/mL (191.51 mM; Need ultrasonic)
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CAS No.: 2456434-36-7
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Research Area: RXR/Cancer
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An orally active retinoid X receptor (RXR) activator with immunomodulatory and antitumor effects. |
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Inhibits iNOS activity and reduces p-ERK protein levels in cancer cells. |
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Significantly decreases the tumor burden and increases the ratio of CD8/CD4, CD25 T cells in immunocompetent models of HER2-positive breast cancer and Kras-driven lung cancer. |
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Solubility: DMSO : 125 mg/mL (326.76 mM; Need ultrasonic)
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CAS No.: 2883540-92-7
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Research Area: PI3K/PI3Kα/Cancer
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A mutant-selective, allosteric and brain-penetrant PI3Kα inhibitor with IC50 values of 9.4 nM and 131 nM for H1047R-mutant and wild-type PI3Kα, respectively. |
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Selectively inhibits all PI3Kα kinase-domain mutant forms in vitro, and potently inhibits the growth of cell lines with both helical- and kinase-domain mutations. |
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Demonstrates robust efficacy in human tumor xenografts without causing the metabolic dysfunction. |
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Solubility: DMSO : 250 mg/mL (622.99 mM; Need ultrasonic)
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CAS No.: 1370032-20-4
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Research Area: Autophagy/Cancer
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An autophagy inhibitor that selectively inhibits autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion. |
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Blocks the recruitment of STX17 to autophagosomes via a UVRAG-dependent mechanism, resulting in the inability of autophagosomes to fuse with lysosomes. |
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Enhances the Cisplatin sensitivity of A549 cells and effectively inhibits autophagy in tumor tissues in vivo. |
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Solubility: DMSO : 41.67 mg/mL (120.99 mM; ultrasonic and warming and heat to 60°C)
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CAS No.: 2913161-19-8
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Research Area: PROTAC/Cancer
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A selective and orally active VHL-based PROTAC SMARCA2 degrader, demonstrates strong selectivity over the highly similar paralogue SMARCA4. |
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Induces near-complete degradation of SMARCA2 in mouse lung cancer xenograft models that leads to tumour growth inhibition. |
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Solubility: DMSO : 125 mg/mL (117.46 mM; Need ultrasonic)
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| Cell Proliferation Detection Kits |
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Cell proliferation assay is a common biological experiment method, and mainly reflects the cell growth, cycle and viability.
Cell proliferation assay is divided into 4 categories according to the detection principle: detection of DNA synthesis, detection of metabolic activity, detection of cell proliferation-related antigens and detection of ATP concentration. The cellular DNA synthesis assay is the most accurate method to detect cell proliferation by determining the amount of cellular DNA synthesis to evaluate the proliferative capacity of cells, which is one of the commonly methods in the research direction of cell proliferation, cell cycle, DNA repair and differentiation, signaling pathways and cell marker tracking.
MCE offers a wide variety of cell proliferation and toxicity assay kits, click here for an up-to-date list of MCE Kits! |
| Catalog No |
Product Name |
| HY-K1084 |
VF 647 Click-iT EdU Universal Cell Proliferation Detection Kit |
| HY-K1085 |
VF 594 Click-iT EdU Universal Cell Proliferation Detection Kit |
| HY-K1086 |
VF 555 Click-iT EdU Universal Cell Proliferation Detection Kit |
| HY-K1087 |
VF 488 Click-iT EdU Universal Cell Proliferation Detection Kit |
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| Natural products against diabetes |
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| Diabetes is an endocrine disease, which can be divided into T1DM and T2DM. T2DM characterized by insulin resistance accounts for more than 90%. At present, diabetes cannot be cured, which not only affects life, but also poses a serious threat to patients' lives due to its complications. Natural products play an important role in the treatment of diabetes. For example, Metformin and Dapagliflozin for diabetes are derivatives from natural products. Up to now, there are still natural products with anti-diabetes effect being discovered continuously. |
| Structure |
Product Name |
Description |
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Dieckol |
Having anti-bacterial, anti-cancer, anti-oxidant, anti-aging, anti-diabetic, neuroprotective actions. |
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Pterosin A |
An orally active anti-diabetic agent, promoting glucose uptake, increasing serum insulin, and improving hyperglycemia and glucose intolerance in diabetic mice. |
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Vomicine |
An alkaloid, showing anti-diabetic activity. |
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Sarsasapogenin |
A sapogenin with antidiabetic, anti-oxidative, anticancer and anti-inflamatory activities. |
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Kukoamine B |
Showing anti-oxidant, anti-acute inflammatory and anti-diabetic properties. |
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| HY-L174 Macrophage Related Compound Library |
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Macrophages are effector cells of the innate immune system, engulfing bacteria and secreting pro-inflammatory and antibacterial mediators. They are an important component of the first line defense against pathogens and tumor cells. In addition, macrophages play an indispensable role in eliminating damaged cells through programmed cell death. Like all immune cells, macrophages originate from pluripotent hematopoietic stem cells in the bone marrow. Macrophages play key functions in many physiological processes beyond homeostasis and innate immunity, including metabolic function, cell debris clearance, tissue repair, and remodeling. In order to fulfill their different functional roles, macrophages can polarize into a series of phenotypes, including classic (pro inflammatory, M1) and alternative (anti-inflammatory, healing promoting, M2) activation states. Macrophages exist in all vertebrate tissues and have a dual function in host protection and tissue damage.
MCE designs a unique collection of 130+ macrophage related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases. |
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| HY-L175 Inflammasomes related Compound Library |
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Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response.
MCE designs a unique collection of 50+ inflammasomes related compounds, mainly targeting the NLRP1, NLRP3, NLRC4 etc. which is an effective tool for development and research of anti-autoimmune disease, anti-cancer. |
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| MCE Isotope-labeled Compounds |
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| Latest Publications Citing Use of MCE Products |
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Cell.
2023 Nov 9;186(23):5114-5134.e27. |
Cancer Cell.
2023 Nov 13;41(11):1911-1926.e8. |
Cancer Cell.
2023 Oct 9;41(10):1731-1748.e8. |
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Products are for research use only and are not intended for human use. We do not sell to patients.
We respect your privacy and do not share or sell your information to third parties. |
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