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| MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use. |
| • Over 50,000 bioactive molecules in stock |
| • Target 1,000+ key proteins in 20+ signaling pathways |
| • Quality reports (LC/MS, NMR and HPLC) for each product |
| • Release more than 1,000 latest biochemicals per month |
| • Data sheet with detailed biological information |
| • High purity & competitive prices |
| • Delivery within 24 hours |
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CAS No.: 141283-87-6
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Research Area: Integrin/Phospholipase/Pancreatitis
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An orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor. |
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Exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site. |
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A phospholipase A2 (PLA2) inhibitor, and can be used for the study of pancreatitis. |
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Solubility: DMSO : 100 mg/mL (263.57 mM; Need ultrasonic)
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CAS No.: 2585648-55-9
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Research Area: Histone Methyltransferase/EED/Cancer
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An exceptionally potent and orally active embryonic ectoderm development (EED) inhibitor. |
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Binds to EED with an IC50 value of 0.2 nM and inhibits KARPAS422 cell growth with an IC50 of 1.2 nM. |
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Shows complete and persistent tumor regression in the KARPAS422 xenograft model. |
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Solubility: DMSO : 25 mg/mL (47.48 mM; Need ultrasonic)
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CAS No.: 1883299-62-4
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Research Area: JAK/Autoimmune Diseases
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An orally active dual JAK1 and TYK2 inhibitor with IC50 values of 17 nM and 23 nM, respectively. |
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Used for the research in various immune system diseases, such as plaque psoriasis. |
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Solubility: DMSO : 125 mg/mL (321.01 mM; Need ultrasonic)
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| Vari Fluor Series Protein Labeling Dyes |
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| Vari Fluor dyes are a new generation of protein fluorescent probes developed by MCE. The fluorescent group binds to the amino group of the protein to form a stable covalent bond, and the fluorescence is highly stable, which makes the fluorescence of the protein fluorescent tracer very good. Meet your experimental needs. |
Product features:
1. Good light stability, stable core structure and active group.
2. High quantum yield, high purity and fluorescence brightness, high signal-to-noise ratio.
3. High water solubility and insensitive to PH. |
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| Natural UV filters for sunscreens |
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| Sunscreens are an important tool used to protect the skin against harmful effects of ultraviolet (UV) radiation. Many natural components are reported to have great potential for use as sunscreen additives in the cosmetics industry. Previous studies have documented that natural components exert their photoprotective effects (such as improved skin elasticity and hydration, skin texture, and wrinkles) through their antioxidant effects, and through the regulation of UV-induced skin inflammation, barrier impairment and aging. |
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Product Name |
Description |
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Violacein |
A secondary metabolite, possessing potent anticancer and antioxidant properties. |
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Scytonemin |
Displays multiple functions, and acts as an effective UV sunscreen and antioxidant. |
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Umbelliferone |
A fluorescing compound of the coumarin family which can be used as a sunscreen agent. |
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Osthole |
A histamine H1 receptor inhibitor with significant UV protection. |
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Octinoxate |
Absorbs UV-B rays from the sun, protecting skin from damage. |
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| Ion Channel Compound Library |
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Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provides pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel is generally classified as sodium (Na+), potassium (K+), calcium (Ca2+), chloride (Cl-), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also has many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important.
MCE designs a unique collection of 1,000+ small molecules related to ion channel, mainly targeting Na+ channel, K+ channel, Ca2+ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases. |
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| MCE Isotope-labeled Compounds |
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| Latest Publications Citing Use of MCE Products |
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Nature.
2023 Oct;622(7981):173-179. |
Nature.
2023 Oct;622(7981):139-148. |
Nature.
2023 Sep;621(7980):830-839. |
Cell.
2023 Sep 28;186(20):4454-4471.e19. |
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Products are for research use only and are not intended for human use. We do not sell to patients.
We respect your privacy and do not share or sell your information to third parties. |
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